Design and Synthesis of Optically Active Trans-Chelating Diphosphine Ligands. Application for Catalytic Asymmetric Synthesis

Abstract

New chiral diphosphines 2,2“-bis[1-(disubstituted phosphino)ethyl]-1,1”-biferrocene, having both central and planar elements of chirality, was designed for a trans-chelating chiral diphosphine ligand (TRAP) for transition metals and synthesized form optically active N,N-dimethyl-1-ferrocenyl ethylamine. Some transition-metal complexes with the TRAP ligands were prepared and utilized as a chiral catalyst for asymmetric synthetic reactions.

Keywords::

• trans-chelating chiral diphosphines
• catalytic asymmetric synthesis