Bifunctional Chelation Systems Based on Hydroxymethyl Phosphine-Based Donor Groups

Abstract

Chelating frameworks based on hydroxymethylene phosphine (HMP) functionalities provides a novel approach to produce chelate-conjugates compatible with development of new Tc-99m and Re-186/188 radiopharmaceuticals. Studies with a bombesin conjugate demonstrates the potential of using HMP-based chelating frameworks to develop radiolabeled receptor-avid agents for targeting cancers.

Keywords::

• hydroxymethylenephosphine
• bioconjugates
• radiopharmaceuticals
• cancer
• Technetium-99m