The Synthesis of Novel Modified Nucleic Acid Monomers and their Subsequent Solid Phase Oligomerisation to Give 3'-Methylene Phosphonate DNA (3MP)

Abstract

A protected hypophosphorus acid synthon allowed selective monoalkylation of hypophosphorus acid with 3'-iodo-methylene thymidine. The resulting H-phosphonous acid was an effective monomer for the solid phase synthesis of 3MP DNA which displayed strong binding to complementary RNA

Keywords::

• antisense
• DNA
• solid phase synthesis