Mechanism of Action of Phosphorylacetic Acid Hydrazides as Memory Enhancers and Neuroptotectors

Introduction

Dementias and amnesias as the result of neurodegenerative diseases or continious ischemia of brain are now recognised as a major problem and affect a significant proportion of the elderly population. The pharmacological treatment of dementia is directed primaraly at correction of neurotransmitter deficits or enchancement of cerebral metabolic activity, but options are limited at present, because neurochemical pathology of dementias also include a disrupted regulation of neurotransmitter systems-signal transduction mechanism, which depends on cell's membranes conditions.