Reaction of Isothiazolones with Amines

Abstract

Both 5-chloro-1-methylisothiazolone (1) and 1-methylisothiazolone (2) are widely used and very effective industrial microbicides. They are routinely used in water cooling towers, metal working fluids, cosmetics (shampoo, conditioners, etc.) to prevent the growth of microorganisms. In a number of these applications there are amines present which tend to degrade the isothiazolone molecule. To come up with a strategy to stabilize these molecules we have studied the reaction of molecules 1 and 2 with amines under different reaction conditions.

Keywords::

• isothiazolones
• amines
• reactions