Variations in MLL Amplification in a Patient with Acute Myeloid Leukemia

Jana Březinová Institute of Hematology and Blood Transfusion, General Faculty Hospital and 1st Medical Faculty, Charles University, U Nemocnice 1, 128 20, Prague, Czech Republic

Zuzana Zemanová Center of Oncocytogenetics, General Faculty Hospital and 1st Medical Faculty, Charles University, Prague, Czech Republic

Jaroslav Čermák Institute of Hematology and Blood Transfusion, General Faculty Hospital and 1st Medical Faculty, Charles University, U Nemocnice 1, 128 20, Prague, Czech Republic

Šárka Kurková Institute of Hematology and Blood Transfusion, General Faculty Hospital and 1st Medical Faculty, Charles University, U Nemocnice 1, 128 20, Prague, Czech Republic

Lenka Šindelářová Center of Oncocytogenetics, General Faculty Hospital and 1st Medical Faculty, Charles University, Prague, Czech Republic

JiřÍ Schwarz Institute of Hematology and Blood Transfusion, General Faculty Hospital and 1st Medical Faculty, Charles University, U Nemocnice 1, 128 20, Prague, Czech Republic

Kyra Michalová Institute of Hematology and Blood Transfusion, General Faculty Hospital and 1st Medical Faculty, Charles University, U Nemocnice 1, 128 20, Prague, Czech Republic

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Abstract

In a 66 years old female patient with acute myeloblastic leukemia (AML) complex chromosomal rearrangements involving 11q23 were diagnosed by G-banding and confirmed by different fluorescence in situ hybridization (FISH) techniques. The amplification of MLL gene differed in various sidelines as shown by locus specific probes for 11q23 and 11q13. Complex karyotype rearrangements involving deletions del(5)(q31) and del(7)(q31) were verified by multicolor fluorescence in situ hybridization (mFISH).

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Variations in MLL Amplification in a Patient with Acute Myeloid Leukemia

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Variations in MLL Amplification in a Patient with Acute Myeloid Leukemia

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