Marked Thrombocytosis Following Relapse of Acute Myeloblastic Leukemia Associated with Development of Translocation (2;14) (p13;q32)

Taizo Tasaka First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan; Department of Medicine, Kagawa Prefectural Central Hospital, Kagawa, Japan

Masami Nagai First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan

Yoshiko Matsuhashi First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan; Department of Medicine, Kagawa Prefectural Central Hospital, Kagawa, Japan

Eisuke Uehara First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan

Naoki Kakazu Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Medicine, Kagawa Prefectural Central Hospital, Kagawa, Japan

Tatsuo Abe Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto, Japan

Takahiro Tamura First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan; Department of Medicine, Kagawa Prefectural Central Hospital, Kagawa, Japan

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Abstract

Thrombocytosis is a rare finding in acute myeloblastic leukemia (AML). Here, we describe a patient with AML who relapsed with marked thrombocytosis. The patient was initially diagnosed as having AML (M4) with a low platelet count. The patient was started on combination chemotherapy including high-dose etoposide and achieved complete remission. However, the patient relapsed six months later with an extremely high platelet count (72.5 2 10 4 / w l). Cytogenetic analysis at relapse revealed the development of t(2;14)(p13;q32). Despite the repeated combination chemotherapy, the patient died with progressive disease. This case suggests that the additional chromosomal aberration t(2;14)(p13;q32) may be related to abnormal thrombocytosis in AML.

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Marked Thrombocytosis Following Relapse of Acute Myeloblastic Leukemia Associated with Development of Translocation (2;14) (p13;q32)

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Marked Thrombocytosis Following Relapse of Acute Myeloblastic Leukemia Associated with Development of Translocation (2;14) (p13;q32)

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