T Cell Lymphoma Associated with Myelofibrosis

Abstract

Myelofibrosis is most frequently associated with certain primary myeloproliferative disorders, but is rare in lymphoid neoplasms. We report the fourth case associated with T-cell lymphoma, involving bone marrow, lymph nodes and spleen. Marked extramedullary hematopoiesis was present. Myelofibrosis subsided completely with response to standard anti-lymphoma combination chemotherapy. Since lymphomatous splenic and bone marrow involvement was minimal in our patient, fibrotic bone marrows should be carefully evaluated for lymphoma.

• T Cell Lymphoma
• Myelofibrosis
• Extramedullary Hematopoiesis
• Pancytopenia