Early Myelodysplastic Syndrome After Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia

Kazuo Muroi Division of Cell Transplantation and Transfusion, Jichi Medical School, Minamikawachi, Tochigi, Japan

Chizuru Kawano Division of Cell Transplantation and Transfusion, Jichi Medical School, Minamikawachi, Tochigi, Japan

Taiji Yokote Division of Hematology, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan

Tetsuya Otsuki Division of Hematology, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan

Keita Kirito Division of Hematology, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan

Norio Komatsu Division of Hematology, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan

Keiya Ozawa Division of Cell Transplantation and Transfusion, Jichi Medical School, Minamikawachi, Tochigi, Japan

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Abstract

A 19-year-old male with de novo acute myeloid leukemia (AML) in complete remission received a bone marrow transplant from a HLA-matched donor. Because of major incompatibility for ABO blood type, bone marrow mononuclear cells of the donor were infused after conditioning including total body irradiation (TBI). Engraftment was confirmed on day +23. On day +91, recipient ABO blood genotype was detected in burst forming-unit erythroid (BFU-E) using polymerase chain reaction. Thereafter, myelodysplastic syndrome (MDS) of recipient origin rapidly developed and progressed into a chronic myelomonocytic leukemia-like disorder. An association between MDS and TBI is suggested.

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Early Myelodysplastic Syndrome After Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia

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Early Myelodysplastic Syndrome After Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia

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