Coexistence of Chronic Neutrophilic Leukemia with Multiple Myeloma

GünÇağ DinÇol Department of Internal Medicine, Division of Hematology, Istanbul Medical School, University of Istanbul, 34390 Çapa, Istanbul, Turkey

Meliha NalÇacI Department of Internal Medicine, Division of Hematology, Istanbul Medical School, University of Istanbul, 34390 Çapa, Istanbul, Turkey

Öner Doğan Division of Pathology, Istanbul Medical School, University of Istanbul, 34390 Çapa, Istanbul, Turkey

Melih Aktan Department of Internal Medicine, Division of Hematology, Istanbul Medical School, University of Istanbul, 34390 Çapa, Istanbul, Turkey

Reyhan KüÇükkaya Department of Internal Medicine, Division of Hematology, Istanbul Medical School, University of Istanbul, 34390 Çapa, Istanbul, Turkey

Mehmet Ağan Division of Pathology, Istanbul Medical School, University of Istanbul, 34390 Çapa, Istanbul, Turkey

Koray DinÇol Department of Internal Medicine, Division of Medical Oncology, Istanbul Medical School, University of Istanbul, 34390 Çapa, Istanbul, Turkey

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Abstract

A case report of simultaneous presentation of chronic neutrophilic leukemia and multiple myeloma (IgG kappa) in a 71-year-old male is described. The patient showed mature neutrophilic leukocytosis, hepatosplenomegaly, high neutrophil alkaline phosphatase score, hyperuricemia, neutrophils with toxic granulation and Döhle bodies, absence of Philadelphia chromosome and of the bcr-abl fusion gene. Moreover, a monoclonal IgG kappa paraproteinemia (36.93 g l m 1 ) was detected. Bence-Jones proteinuria was 3.84 g l m 1. The bone marrow was grossly hypercellular with marked myeloid hyperplasia and aggregates of plasma cells. The patient died of severe bronchopneumonia after the transformation of chronic neutrophilic leukemia to acute myelomonocytic leukemia, 1.5 years following diagnosis.

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Coexistence of Chronic Neutrophilic Leukemia with Multiple Myeloma

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Coexistence of Chronic Neutrophilic Leukemia with Multiple Myeloma

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