Human Herpes Virus-8-Negative Primary Effusion Lymphoma in a Patient with Common Variable Immunodeficiency

Abstract

Primary effusion lymphoma (PEL) is a newly described high-grade B cell lymphoma developing in association with human herpes virus type 8 (HHV-8) in human immunodeficiency virus (HIV)-infecting individuals. Common variable immunodeficiency (CVID) is a primary immunodeficiency disease characterized by reduced serum immunoglobulin and heterogeneous clinical features. The risk of cancer in CVID patients is increased. Here, we describe a PEL that developed in the pleural and pericardial cavities of an HIV-negative and HHV-8-negative patient with CVID.

• Primary Effusion Lymphoma
• Common Variable Immunodeficiency
• Human Herpes Virus 8
• Non-Hodgkin's Lymphoma