Abnormal Cytogenetics and Significant Bone Marrow Plasmacytosis are Predictive of Early Progression and Short Survival in Patients with Low Tumor Mass Asymptomatic Multiple Myeloma

Stephane Depil Service des Maladies du Sang Hôpital Claude Huriez, CHU rue Michel Polonovski 59037 Lille France

Xavier Leleu France Laboratoire de Cytogénétique CHU 59037 Lille France

Jean-Baptiste Micol Service des Maladies du Sang Hôpital Claude Huriez, CHU rue Michel Polonovski 59037 Lille France

Celine Berthon France Laboratoire de Cytogénétique CHU 59037 Lille France

Jean Luc Laï Service des Maladies du Sang Hôpital Claude Huriez, CHU rue Michel Polonovski 59037 Lille France

Francis Bauters France Laboratoire de Cytogénétique CHU 59037 Lille France

Bruno Quesnel Service des Maladies du Sang Hôpital Claude Huriez, CHU rue Michel Polonovski 59037 Lille France

Thierry Facon France Laboratoire de Cytogénétique CHU 59037 Lille France

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Abstract

In order to evaluate the prognostic factors for progression and survival in patients with a low tumor mass asymptomatic multiple myeloma (MM), we studied 59 patients who had a long term follow-up. Cytogenetic abnormalities (using conventional cytogenetics) were observed in 14 out of 45 analyzable patients (31%). An abnormal karyotype and a bone marrow (BM) plasmacytosis > 15% were found to be adverse prognostic factors for progression in univariate and multivariate analysis.

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Abnormal Cytogenetics and Significant Bone Marrow Plasmacytosis are Predictive of Early Progression and Short Survival in Patients with Low Tumor Mass Asymptomatic Multiple Myeloma

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Abnormal Cytogenetics and Significant Bone Marrow Plasmacytosis are Predictive of Early Progression and Short Survival in Patients with Low Tumor Mass Asymptomatic Multiple Myeloma

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