Marked Elevation of Soluble Fas Ligand and Cytokine Secretion after Splenectomy in Aggressive Natural Killer Cell Leukemia/Lymphoma

Kiyohiko KaizU Department of Pediatrics Nippon Medical School 1-1-5, Sendagi Bunkyo-ku, Tokyo 113-8603 Japan

Miho Maeda Department of Pediatrics Nippon Medical School 1-1-5, Sendagi Bunkyo-ku, Tokyo 113-8603 Japan

Takuya Ohkawa Department of Pediatrics Nippon Medical School 1-1-5, Sendagi Bunkyo-ku, Tokyo 113-8603 Japan

Mari Hayashida Department of Pediatrics Nippon Medical School 1-1-5, Sendagi Bunkyo-ku, Tokyo 113-8603 Japan

Seiko Nakajima Department of Pediatrics Ageo Central General Hospital 1-10-10, Kashiwaza Ageo-shi, Saitama-ken 362-8588 Japan

Yuichi Sugisaki Department of Pathology Nippon Medical School 1-1-5, Sendagi Bunkyo-ku, Tokyo 113-8603 Japan

Yoshitaka Fukunaga Department of Pediatrics Nippon Medical School 1-1-5, Sendagi Bunkyo-ku, Tokyo 113-8603 Japan

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Abstract

We report a case of Epstein - Barr virus-associated aggressive natural killer cell leukemia/lymphoma with giant splenomegaly in which splenectomy resulted in progression of apoptosis and hemophagocytosis. The serum level of ferritin, triglycerides, interferon-γ (IFN-γ), interleukin 10 (IL-10), and soluble Fas ligand (sFasL) increased markedly, and liver damage progressed after splenectomy. The number of apoptotic cells in peripheral blood smears increased following splenectomy. In the present case, splenectomy caused disruption of the cytokine network, resulting in apoptosis of blood cells and hepatocytes, as well as phagocytosis.

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Marked Elevation of Soluble Fas Ligand and Cytokine Secretion after Splenectomy in Aggressive Natural Killer Cell Leukemia/Lymphoma

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Marked Elevation of Soluble Fas Ligand and Cytokine Secretion after Splenectomy in Aggressive Natural Killer Cell Leukemia/Lymphoma

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