Viral Load of Human Herpesvirus 8 (HHV-8) in the Circulatory Blood Cells Correlates with Clinical Progression in a Patient with HHV-8-associated Solid Lymphoma with AIDS-associated Kaposi's Sarcoma

Jian Song Department of Medical Science I, School of Health and Sport Sciences Osaka University Osaka Japan

Atsushi Yoshida Department of Infection Control and Prevention, Graduate School of Medicine University of Tokyo Tokyo Japan

Yoshihiko Yamamoto AIDS Clinical Center International Medical Center of Japan Tokyo Japan

Harutaka Katano Department of Pathology National Institute of Infectious Diseases Tokyo Japan

Keisuke Hagihara Department of Medical Science I, School of Health and Sport Sciences Osaka University Osaka Japan

Shinichi Oka AIDS Clinical Center International Medical Center of Japan Tokyo Japan

Satoshi Kimura Department of Medical Science I, School of Health and Sport Sciences Osaka University Osaka Japan

Kazuyuki Yoshizaki Department of Medical Science I, School of Health and Sport Sciences Osaka University Osaka Japan

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Abstract

We encountered a case of a rapidly progressive HHV-8-associated solid lymphoma with AIDS-associated Kaposi's sarcoma (KS). HHV-8 DNA load in whole blood cells was analyzed quantitatively by real-time PCR using amplification of the HHV-8-encoded ORF26 gene. Ours is the first observation that the rapid increase in the HHV-8 viral load (from 1.9 × 10⁴ copies/μg to 1.6 × 10⁶ copies/μg in 40 days) in conjunction with low CD4 + cell counts was accompanied by an accelerated clinical disease progression. The results indicate that the quantity of circulating HHV-8 is measurable with real-time PCR and can provide clinically useful information.

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Viral Load of Human Herpesvirus 8 (HHV-8) in the Circulatory Blood Cells Correlates with Clinical Progression in a Patient with HHV-8-associated Solid Lymphoma with AIDS-associated Kaposi's Sarcoma

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Viral Load of Human Herpesvirus 8 (HHV-8) in the Circulatory Blood Cells Correlates with Clinical Progression in a Patient with HHV-8-associated Solid Lymphoma with AIDS-associated Kaposi's Sarcoma

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