The natural history of a novel, systemic, disseminated model of syngeneic mouse B-cell lymphoma

Michael J. Passineau Department of Medicine, University of Alabama at Birmingham, AL 35291, USA; Department of Pathology, University of Alabama at Birmingham, AL 35291, USA; Department of Surgery, University of Alabama at Birmingham, AL 35291, USA; Department of Gene Therapy, University of Alabama at Birmingham, AL 35291, USA

Gene P. Siegal Department of Pathology, University of Alabama at Birmingham, AL 35291, USA; Department of Surgery, University of Alabama at Birmingham, AL 35291, USA; Department of Cell Biology, University of Alabama at Birmingham, AL 35291, USA; Department of Gene Therapy, University of Alabama at Birmingham, AL 35291, USA

Maaike Everts Department of Medicine, University of Alabama at Birmingham, AL 35291, USA; Department of Pathology, University of Alabama at Birmingham, AL 35291, USA; Department of Surgery, University of Alabama at Birmingham, AL 35291, USA; Department of Gene Therapy, University of Alabama at Birmingham, AL 35291, USA

Alexander Pereboev Department of Medicine, University of Alabama at Birmingham, AL 35291, USA; Department of Pathology, University of Alabama at Birmingham, AL 35291, USA; Department of Surgery, University of Alabama at Birmingham, AL 35291, USA; Department of Gene Therapy, University of Alabama at Birmingham, AL 35291, USA

Darshana Jhala Department of Pathology, University of Alabama at Birmingham, AL 35291, USA; Department of Surgery, University of Alabama at Birmingham, AL 35291, USA; Department of Cell Biology, University of Alabama at Birmingham, AL 35291, USA; Department of Gene Therapy, University of Alabama at Birmingham, AL 35291, USA

Minghui Wang Department of Medicine, University of Alabama at Birmingham, AL 35291, USA; Department of Pathology, University of Alabama at Birmingham, AL 35291, USA; Department of Surgery, University of Alabama at Birmingham, AL 35291, USA; Department of Gene Therapy, University of Alabama at Birmingham, AL 35291, USA

Zeng B. Zhu Department of Medicine, University of Alabama at Birmingham, AL 35291, USA; Department of Pathology, University of Alabama at Birmingham, AL 35291, USA; Department of Surgery, University of Alabama at Birmingham, AL 35291, USA; Department of Gene Therapy, University of Alabama at Birmingham, AL 35291, USA

Sangae Kim Park Department of Medicine, University of Alabama at Birmingham, AL 35291, USA; Department of Pathology, University of Alabama at Birmingham, AL 35291, USA; Department of Surgery, University of Alabama at Birmingham, AL 35291, USA; Department of Gene Therapy, University of Alabama at Birmingham, AL 35291, USA

David T. Curiel Department of Medicine, University of Alabama at Birmingham, AL 35291, USA; Department of Pathology, University of Alabama at Birmingham, AL 35291, USA; Department of Surgery, University of Alabama at Birmingham, AL 35291, USA; Department of Gene Therapy, University of Alabama at Birmingham, AL 35291, USA

Gina M. Nelson Department of Neurobiology and the Clinical Nutrition Research Centar, University of Alabama at Birmingham, AL 35291, USA

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Abstract

Lymphomas and leukemias, neoplasms of hematopoetic lineage, pose unique challenges that require novel treatment paradigms. The inter-relationship between the immune system and the neoplastic lesion in these diseases dictates that, to evaluate novel therapies, models are needed that mimic human disease in an immunocompetent host. In the present study, we describe a disseminated, syngeneic model of B-cell lymphoma in the Balb/c mouse based upon the A20 cell line. This model mimics aspects of diffuse large B-cell lymphomas in humans, and recapitulates para-spinous tumor growth, bone destruction and nerve root compression, which may complicate disseminated disease. Furthermore, this tumor expresses a key marker of interest, CD40, which is a candidate for tumor-specific vector targeting via current modalities. The present study therefore describes a high-fidelity model of disseminated lymphoma with implications for novel targeted therapeutics. Lymphomas and leukemias, neoplasms of hematopoetic lineage, pose unique challenges that require novel treatment paradigms. The inter-relationship between the immune system and the neoplastic lesion in these diseases dictates that, to evaluate novel therapies, models are needed that mimic human disease in an immunocompetent host. In the present study, we describe a disseminated, syngeneic model of B-cell lymphoma in the Balb/c mouse based upon the A20 cell line. This model mimics aspects of diffuse large B-cell lymphomas in humans, and recapitulates para-spinous tumor growth, bone destruction and nerve root compression, which may complicate disseminated disease. Furthermore, this tumor expresses a key marker of interest, CD40, which is a candidate for tumor-specific vector targeting via current modalities. The present study therefore describes a high-fidelity model of disseminated lymphoma with implications for novel targeted therapeutics.

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The natural history of a novel, systemic, disseminated model of syngeneic mouse B-cell lymphoma

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The natural history of a novel, systemic, disseminated model of syngeneic mouse B-cell lymphoma

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