Wilms' tumor gene (WT1) is predominantly expressed in clonal hematopoietic cells in myelodysplastic syndromes

Dr Xiao Li Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, ChinaCorrespondence[email protected]

Lingyun Wu Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, China

Shaoxu Ying Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, China

Chunkang Chang Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, China

Quan Pu Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, China

Abstract

To determine the expression of Wilms' tumor gene (WT1) in clonal hematopoietic cells in patients with myelodysplastic syndromes (MDS), immunochemistry labelling (alkaline phosphatase anti-alkaline phosphatase) and fluorescence in situ hybridization (FISH) were coperformed on bone marrow cytospins from 18 patients whose abnormal karyotypes had been determined by G-binding analysis. Compared to 12 healthy donors, WT1 positive nucleated cells in MDS marrows were significantly higher (t = 2.30; P = 0.032). Moreover, WT1 was expressed predominantly in MDS clonal cells (with abnormal FISH signals) rather than in non-clonal cells (residual normal cells) (t = 2.19; P = 0.043).

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Wilms' tumor gene (WT1) is predominantly expressed in clonal hematopoietic cells in myelodysplastic syndromes

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Wilms' tumor gene (WT1) is predominantly expressed in clonal hematopoietic cells in myelodysplastic syndromes

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