F-18-fluoro-deoxy-glucose positron emission tomography in the assessment of peripheral T-cell lymphomas

S. Bishu National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USACorrespondence[email protected]

J. M. Quigley College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

J. Schmitz College of Medicine, Creighton University Medical Center, Omaha, NE, USA

S. R. Bishu Department of Pathology, Northwestern University Medical Center

R. A. Stemm College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

S. M. Olsasky College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

S. Paknikar Division of Nuclear Medicine, Department of Radiology, Creighton University Medical Center, Omaha, NE, USA

K. H. Holdeman Division of Nuclear Medicine, Department of Radiology, University of Nebraska Medical Center, Omaha, NE, USA

J. O. Armitage Section of Hematology and Oncology, Department of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

J. H. Hankins Division of Nuclear Medicine, Department of Radiology, University of Nebraska Medical Center, Omaha, NE, USA

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Abstract

F-18-fluoro-deoxy-glucose positron emission tomography (PET) is highly sensitive and specific in the imaging of B-cell lymphomas. In contrast, its utility in the diagnostic evaluation of T-cell lymphomas is less defined. In this article, we present our finding utilizing PET in peripheral T-cell lymphomas (PTCL). A retrospective review of patients who underwent PET examinations at our institution produced 24 PET examinations among patients with PTCL. A lesion-based analysis was undertaken to evaluate the diagnostic accuracy of PET in PTCL. PET findings were compared with a standard of reference and sensitivity, specificity, positive and negative predictive values were calculated. PET had an overall sensitivity of 86% and specificity of 100%. PET had high sensitivity (95%) at nodal and non-cutaneous extra-nodal sites and poor sensitivity (13%) at cutaneous sites. The mean SUV of abnormal foci in anaplastic large cell lymphoma was 11 mg/ml (range: 3 – 40), and PTCL-unclassified was 8 mg/ml (range: 1 – 23).

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F-18-fluoro-deoxy-glucose positron emission tomography in the assessment of peripheral T-cell lymphomas

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F-18-fluoro-deoxy-glucose positron emission tomography in the assessment of peripheral T-cell lymphomas

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