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Mechanisms of action of antithymocyte globulin: old dogs with new tricks!

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Pages 1664-1667 | Received 20 Apr 2008, Accepted 24 Apr 2008, Published online: 01 Jul 2009
 

Abstract

Understanding the mechanisms underlying immunological tolerance is the key to successful transplantation. Recent findings demonstrate that polyclonal antibodies such as the antithymocyte globulins preparations can provide wide spectrum immunomodulation, suggesting that their use in the immunosuppression therapeutic armamentarium may help in reducing the incidence of organ rejection and improving patients’ outcome after hematopoietic stem cell transplantation.

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