OncomiR or antioncomiR: Role of miRNAs in Acute Myeloid Leukemia

Abstract

Acute Myeloid Leukemia (AML) is a hematopoietic progenitor/stem cell disorder in which neoplastic myeloblasts are stopped at an immature stage of differentiation and lost the normal ability of proliferation and apoptosis. MicroRNAs (miRNAs) are small noncoding, single-stranded RNA molecules that can mediate the expression of target genes. While miRNAs mean to contribute the developments of normal functions, abnormal expression of miRNAs and regulations on their corresponding targets have often been found in the developments of AML and described in recent years. In leukemia, miRNAs may function as regulatory molecules, acting as oncogenes or tumor suppressors. Overexpression of miRNAs can down-regulate tumor suppressors or other genes involved in cell differentiation, thereby contributing to AML formation. Similarly, miRNAs can down-regulate different proteins with oncogenic activity as tumor suppressors. We herein review the current data on miRNAs, specifically their targets and their biological function based on apoptosis in the development of AML.

Keywords:

• OncomiR
• antioncomiR
• Acute Myeloid Leukemia
• microRNA

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2018.1480769.

Additional information

Funding

This study was supported by the National Natural Science Foundation of China (Grant No. 31470041) and the Foundation of Science and Technology Office in Luzhou (Grant No. 2016-S-65(7/9)).

Notes on contributors

Chengcheng He

Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.

Bo Luo

Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.

Nan Jiang

Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.

Yu Liang

Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.

Yancheng He

Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.

Jingyuan Zeng

Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.

Jiajia Liu

Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.

Xiaoli Zheng

Conceived and designed the paper: CC He, B Luo. Drew the figure: N Jiang, Y Liang. Analyzed the reference: YC He, JY Zeng, JJ Liu. Wrote the paper: XL Zheng, CC He.