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Abstract
T-cell acute lymphoblastic leukemia (T-ALL) is a curable malignancy in the pediatric population. However, population-level data on its incidence and outcomes among adults is sparse. Using SEER database, we identified 1141 patients aged ≥20 years with pathologically confirmed T-ALL diagnosed between the years 2001 and 2014 and actively followed. Incidence of T-ALL was 0.13 cases/100,000 population with significant variations by age, gender, race, and period. The 5-year overall survival (OS) declined significantly with increasing age (age <40, 51.9%; age 40–59, 37.3%; age 60–79, 19.2%; age ≥80, 0%; p < .001) and varied by race (whites – 45.7%, blacks – 25.1%, others – 40.3%; p < .001). Over time, OS has improved significantly in patients <60 years (2001–2007, 42.8% vs 2008–2014, 53.1%; p = .005), but not in patients older than 60 years (2001–2007, 18% vs 2008–2014, 22.8%; p = .71), highlighting the need for effective and safe treatments in this population.
Potential conflict of interest
Disclosure forms provided by the authors are available with the full text of this article online at at http://dx.doi.org/10.1080/10428194.2018.1522442