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Leukemia & Lymphoma Volume 60, 2019 - Issue 9
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Letters to the Editor

CCGG deletion (rs201074739) in CD33 results in premature termination codon and complete loss of CD33 expression: another key variant with potential impact on response to CD33-directed agents

Ioannis PapageorgiouDepartment of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, USA; ;Center for Pharmacogenetics, College of Pharmacy, University of Florida, Gainesville, FL, USA; View further author information
,
Michael R. LokenHematologics Inc, Seattle, WA, USA; View further author information
,
Lisa Eidenschink BrodersenHematologics Inc, Seattle, WA, USA; View further author information
,
Mohammed GbadamosiDepartment of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, USA; ;Center for Pharmacogenetics, College of Pharmacy, University of Florida, Gainesville, FL, USA; View further author information
,
Geoffrey L. UyDivision of Oncology, Washington University, St Louis, MI, USA; View further author information
,
Soheil MeshinchiClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USAView further author information
&
Jatinder K. LambaDepartment of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, USA; ;Center for Pharmacogenetics, College of Pharmacy, University of Florida, Gainesville, FL, USA; Correspondence[email protected]
View further author information
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Pages 2287-2290 | Received 29 Nov 2018, Accepted 02 Jan 2019, Published online: 05 Feb 2019
 
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Acknowledgements

We are thankful to funding from University of Florida Cancer Center to support the work. We are also thankful to St. Baldrick’s Foundation and Children’s oncology group for supporting CD33 variant study. We are thankful to Ms. Laura Pedro for running the flow-cytometric analysis on cell lines.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2019.1569232.

Additional information

Funding

This work was supported by NIH/NCI grants awarded to R21CA-155524 and R01CA-132946.

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