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Original Articles

Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia – a distinct subtype with favorable prognosis

Musa Yilmaza Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Hagop M. Kantarjiana Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Gokce Torunerb Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

C. Cameron Yinb Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Rashmi Kanagal-Shamannab Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

https://orcid.org/0000-0001-7829-5249

Jorge E. Cortesc Georgia Cancer Center, Augusta University, Augusta, GA, USA

https://orcid.org/0000-0002-8636-1071

Ghayyas Issaa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Nicholas J. Shorta Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Joseph D. Khouryb Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Guillermo Garcia-Maneroa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Farhad Ravandia Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Tapan Kadiaa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Marina Konoplevaa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

William G. Wierdaa Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Nitin Jaina Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Zeev Estrova Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

https://orcid.org/0000-0002-1623-3613

Koji Sasakia Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Sherry Piercea Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Susan M. O'Briend Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA, USA

Elias J. Jabboura Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence[email protected]

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Abstract

The recurring translocation t(1;19) (q23;p13) with TCF3-PBX1 rearrangements are uncommon in adult acute lymphoblastic leukemia (ALL), and their prognostic impact remains to be described in the era of modern chemotherapies. We investigated 427 adult patients with newly diagnosed pre-B ALL, 16 (4%) had t(1;19)(q23;p13) at diagnosis. All 16 patients achieved complete remission after induction with intensive chemotherapy, and with a median of 7-year follow-up, 2 relapsed. The 5-year cumulative incidence of relapse and overall survival rates were 14% and 82%, respectively. Our analysis showed that adult patients with t(1;19)(q23;p13) positive ALL had favorable prognosis with intensive chemotherapy regimens.

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Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia – a distinct subtype with favorable prognosis

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Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia – a distinct subtype with favorable prognosis

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