The association between non-steroidal anti-inflammatory drugs (NSAIDs) and myelodysplastic syndromes in the Adults in Minnesota with Myelodysplastic Syndromes (AIMMS) Study

Abstract

Myelodysplastic syndromes (MDS) are a heterogeneous group of blood disorders. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a chemopreventive effect in some cancers. We evaluated associations between NSAID use and MDS in a population-based case-control study. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Secondary analyses stratified by sex and MDS subtype were also conducted.The analysis included 399 MDS cases and 698 controls. No significant associations between MDS and use of aspirin (OR = 0.87, 95% CI 0.67–1.14), ibuprofen (OR = 0.91, 95% CI 0.64–1.30), acetaminophen (OR = 1.29, 95% CI 0.90–1.84) or NSAIDs overall (OR = 0.92, 95% CI 0.68–1.23) were observed. No significant associations were observed in models stratified by sex or MDS subtype; however, the direction of the effect between NSAID use and MDS varied by MDS subtype. Our results do not support an association between NSAID use and MDS overall.

Keywords:

• Myelodysplastic syndromes
• epidemiology
• non-steroidal anti-inflammatory drug

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

Data are available by request from the investigators.

Additional information

Funding

The study was funded by a National Institutes of Health grant [R01 CA142714 to J.N.P] and supported by a grant from the National Institutes of Health [T32 CA099936 to A.K.H].