https://orcid.org/0000-0002-1491-5514
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Abstract
Compared to Asian and Latin American populations, sinonasal NK- or T-cell lymphoma is rare in Europe. All patients with sinonasal NK- or T-cell lymphoma in Denmark from 1980 to 2017 were validated histologically, and the disease behavior and demographics were extracted from medical records and national registries. Prognostic factors associated with mortality were determined using survival statistics. We included 56 patients: 40 extranodal NK/T-cell lymphoma (nasal type) (ENKTCL) and 16 peripheral T-cell lymphoma (not otherwise specified) (PTCL). The median age was 66, and most patients were male (72%). The ENKTCL and PTCL 5-year overall survival was 48% and 50%, respectively; progression-free survival was 38% for both. With ENKTCL, stage and performance status increased mortality significantly (HR = 8.6; p < 0.001 and HR = 4.23; p = 0.04). In conclusion, disseminated disease had a dismal outcome and the onset of ENKTCL in this ethnically homogeneous European cohort was about a decade later than reported in Asian populations.
Ethics statement
The study was authorized by the Scientific Ethics Committee of the Capital Region of Denmark (file no. H-16023080) and the Danish Data Protection Agency (file no. P-2020-588).
Consent form
Written informed consent was obtained from the patient with regards to publication of pictures and diagnostic imaging specifically for this publication.
Disclosure statement
The authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest.
Correction Statement
This article was originally published with errors, which have now been corrected in the online version. Please see Correction (http://dx.doi.org/[10.1080/10428194.2023.2255364)