Nasal Lymphomas in Japan: A High Prevalence of Epstein-Barr Virus Type A and Deletion Within the Latent Membrane Protein Gene

Junji Suzumiya First Department of Pathology, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, Japan; Internal Medicine, School of Medicine, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, JapanCorrespondence[email protected]

Koichi Ohshima First Department of Pathology, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, Japan

Morishige Takeshita First Department of Pathology, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, Japan

Motonobu Kanda First Department of Pathology, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, Japan; Internal Medicine, School of Medicine, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, Japan

Chika Kawasaki First Department of Pathology, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, Japan; Internal Medicine, School of Medicine, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, Japan

Nobuhiro Kimura Internal Medicine, School of Medicine, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, Japan

Kazuo Tamura Internal Medicine, School of Medicine, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, Japan

Masahiro Kikuchi First Department of Pathology, Fukuoka University, Nanakuma 7–5–1, Jonan-ku, Fukuoka, 814–0180, Japan

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Abstract

The majority of nasal lymphomas are of the natural killer (NK)/T cell lineage. We analyzed 33 specimens of nasal lymphoma from Japanese patients for Epstein-Barr virus (EBV). Phenotypic and genetic analyses showed 28 cases with NK/T cell type and 5 cases with B cell type. All NK/T lymphomas were of pleomorphic cell type except 2 large cell (centroblastoid) and one lymphoblastic lymphoma. All cases with nasal B cell lymphoma were of large (centroblastoid) cell type. EBV was detected in all cases of NK/T cell type with the exception of one lymphoblastic case, and was monoclonally integrated in all cases examined (14/14 cases). All but one case had subtype A of EBV infection with 30-base paired deleted LMP-1 gene. One case of B cell lymphoma showed the presence of EBV infection with subtype A and deletion of LMP-1. Our results indicate that the majority of nasal lymphomas in Japanese patients are of the nasal NK/T cell type, have pleomorphic morphology, a high prevalence of EBV with a monoclonal integration, subtype A and deleted LMP-1 gene. In contrast, nasal B cell lymphoma showed monomorphic appearance and rare EBV infection.

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Nasal Lymphomas in Japan: A High Prevalence of Epstein-Barr Virus Type A and Deletion Within the Latent Membrane Protein Gene

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Nasal Lymphomas in Japan: A High Prevalence of Epstein-Barr Virus Type A and Deletion Within the Latent Membrane Protein Gene

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