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Abstract
Researchers from the National Institute for Occupational Safety and Health (NIOSH) investigated the use of a biological safety cabinet (BSC) in connection with an exposure to Legionella pneumophila at a research facility laboratory. The exposure occurred during the handling of bacteria-containing solutions associated with the analysis of water samples. Inhalation of the bacteria was thought to be the most likely exposure route. Bacteria escaping from the BSC via inadequate filtration of cabinet exhaust air or via leaks in the cabinet structure were considered to be two possible exposure mechanisms. Our investigation included consideration of the following issues related to BSCs: 1) the types of BSCs available for specific applications, 2) certification of the cabinets, 3) information available to users regarding cabinet uses and limitations, and 4) recordkeeping. This article briefly discusses the aforementioned issues and summarizes recommendations as they relate to an industrial hygiene program or investigation dealing with BSCs. The article is intended to provide basic information to industrial hygiene managers or investigators who may have limited familiarity with the subject of BSCs. Relevant references for more detailed information regarding BSCs are also noted.