Assignment of Skin Notation for Threshold Limit Values Chemicals Based on Acute Dermal Toxicity

Abstract

The skin notation with a threshold limit value (TLV) indicates that significant quantities of the chemical may be absorbed through that route to produce unwanted systemic effects. The relationship between the dermal LD₅₀ for a given chemical and the occurrence of skin irritation in the TLV was examined. An association was found, but it was weak. We suggest that all chemicals found to have LD₅₀ values lower than 1000 mg/kg be initially assigned a skin notation until more definitive work proves otherwise. Further, effects that can be produced following repeated dermal exposures using reasonable dose concentrations need to be evaluated for the purpose of a skin notation. Extrapolation of dermal effects following information from other routes of administration needs to be carefully considered, particularly when the absorption and distribution of the chemical following various routes (including dermal) are known. Kennedy, G.L., Jr.; Brock, W.J.; Banerjee, A.K.: Assignment of Skin Notation for Threshold Limit Values Chemicals Based on Acute Dermal Toxicity. Appl. Occup. Environ. Hyg. 8(1)26-30; 1993.