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Abstract
Segregation distortion of alleles was found in several regions of the genome in allele type analyses of genetic markers for a swine resource family that had been constructed by crossing Gottingen miniature pig and Meishan breeds. From these regions, a region on chromosome 6 presented a distortion over several consecutive markers. This chromosome 6 region was subsequently further investigated to reveal that alleles of a chromosome 6 homologue of the Gottingen miniature pig were not found in a homozygous family member. The litter size of F1‐crosses which were able to produce homozygotes in this region were 24% smaller, on average, than F1‐crosses which were unable to produce homozygotes. This indicated that this region of the chromosome 6 homologue contained a recessive gene or genes which could terminate fetal development. An additional 10 markers were subsequently used to investigate the region more precisely. These studies revealed that this region spans 7 cM and is located between markers Sw855 and Swl22. Since current comparative maps show that this region corresponds to the human chromosome 19 q‐arm, genes positioned on the human chromosome 19 q‐arm were screened to select 20 candidate genes. These included the pregnancy‐specific beta‐1‐glycoprotein gene.
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