Anti-Ulcerogenic and Gastric Antisecretory Effects of Corchorus olitorius Extract in Male Albino Rats

B. V. OwoyeleDepartment of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria

W. AbdulmajeedDepartment of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, NigeriaCorrespondence[email protected] [email protected]

B. M. AdisaDepartment of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria

O. O. OwolabiDepartment of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria

S. A. OyelekeDepartment of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria

Abstract

Anti-ulcerogenic and gastric anti-secretory activity of aqueous extract of Cochorus olitorius was investigated in HCl/ethanol and indomethacin-induced gastric lesions in male albino rats. Pre-treatment with aqueous extract (50, 100, or 200 mg.kg⁻¹) orally for 2 weeks reduced ulcer formation, except those pre-treated with 50 mg.kg⁻ in the indomethacin model. In both models, the decrease in gastric acid production was dose-dependent.

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Anti-Ulcerogenic and Gastric Antisecretory Effects of Corchorus olitorius Extract in Male Albino Rats

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Anti-Ulcerogenic and Gastric Antisecretory Effects of Corchorus olitorius Extract in Male Albino Rats

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