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Abstract
Present study focused the antidiabetic activity of n-hexane fraction of hydro-methanolic (2:3) extract of Swietenia mahagoni seed in steptozotocin (STZ) induced diabetic rat. Significant increased in the levels of fasting blood glucose, glyclated hemoglobin and diminution in hepatic hexokinase, glucose-6-phosphate dehydrogenase, catalase, peroxidase, superoxide dismutase and elevation in glucose-6-phosphatase activities in diabetic animals. Said biosensors were significantly recovered towards the control after treatment of n-hexane fraction than other fractions. Renotoxic (serum urea, uric acid and creatinine) and hematoxic (red blood cell count, platelet index and erythrocyte sedimentation rate) biosensors were significantly recovered towards control after n-hexane fraction treatment to diabetic group. Results suggest that n-hexane fraction has more potent non-toxic antidiabetic efficacy.
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