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Original Articles

Digested Moringa oleifera Boiled Pod Exhibits Anti-Inflammatory Activity in Caco-2 Cells

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Pages 148-160 | Received 05 Dec 2013, Published online: 20 Aug 2014
 

Abstract

Pretreatment of Caco-2 cells with the bioaccessible fraction of bMO suppressed IL-1β-induced COX-2, IL-8 and MCP-1 and intracellular ROS content. Omission of bile extract during digestion decreased the extent of inhibitory effect of digested bMO on IL-1β activated IL-8 and MCP-1 production. Both lipophilic and hydrophilic compounds of bMO contribute to suppressive response to the pro-inflammatory insult, but only the hydrophilic compounds are responsible for its antioxidant activity. The suppressive effect of the bioaccessible fraction of bMO was partly modulated by inhibiting the phosphorylation of p-38 and IκB. These data provide supportive health promoting activity of M. oleifera pods on the gut.

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