Phytochemicals, Antihemolytic, Anti-inflammatory, Antioxidant, and Antibacterial Activities from Thymus Algeriensis

Mouna MokhtariLaboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, Batna, Algeria

Sonia ChabaniLaboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, Batna, Algeria

Soumia MouffoukLaboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, Batna, Algeria

Mohamed-Cherif AberkaneLaboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, Batna, Algeria

Ammar DibiLaboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, Batna, Algeria

Mohammed BenkhaledLaboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, Batna, Algeria

Hamada HabaLaboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, Batna, AlgeriaCorrespondence[email protected] [email protected]

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ABSTRACT

The chemical composition and anti-inflammatory, antihemolytic, antioxidant, and antibacterial activities of solvent extracts of Thymus algeriensis in petroleum ether, chloroform, and n-butanol were evaluated. Ten compounds including four flavonoids, four phenolics, and two triterpenoids were isolated and identified by chromatography and spectroscopy. The n-butanol extract had the greatest antioxidant activity and inhibited hemolysis with a value of IC₅₀ at 322.85 ± 0.87 µg mL⁻¹. The chloroform extract exhibited the highest anti-inflammatory effect with 45.27% inhibition. The extracts demonstrated antibacterial activity against the tested strains.

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Acknowledgments

The authors are grateful to the DGRSDT and the Ministry of Higher Education and Scientific Research of Algeria for PRFU Project (B00L01UN050120180001), and the team of Natural Substances Chemistry, Institute of Molecular Chemistry, Reims (ICMR) - UMR CNRS 7312, Reims University France for providing technical support.

Disclosure Statement

No potential conflict of interest was reported by the authors.

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Phytochemicals, Antihemolytic, Anti-inflammatory, Antioxidant, and Antibacterial Activities from Thymus Algeriensis

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Phytochemicals, Antihemolytic, Anti-inflammatory, Antioxidant, and Antibacterial Activities from Thymus Algeriensis

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