Hepatoprotective and Antioxidant Roles of Priva Cordifolia Leaf Extracts on HepG2 Cell Line

ABSTRACT

The phytochemical constituents in Priva cordifolia leaf extracts and their antibacterial activity against Escherichia coli and Pseudomonas sp. were determined along with antioxidant property . HepG2 cells were used to test the hepatoprotective and cytoprotective effects of P. cordifolia leaf extracts by evaluating the levels of liver enzymes AST and ALT. The inhibitory zone against E. coli and Pseudomonas sp.       by the ethanolic extract was effective than     the aqueous extract. At 100 µg mL⁻¹, the ethanolic extract had the highest Fe³⁺ reducing ability of 89.52% and improved cell viability and decreased AST and ALT levels in CCl₄-damaged HepG2 cells.

KEYWORDS:

• Jaundice
• antibacterial

Disclosure statement

No potential conflict of interest was reported by the author(s).

Supplemental data

Supplemental data for this article can be accessed online at https://doi.org/10.1080/10496475.2024.2315244.