A light microscopic investigation of the renoprotective effects of α-lipoic acid and α-tocopherol in an experimental diabetic rat model

Elif Kayhan KuştepeDepartment of Histology and Embryology, Medical Faculty, Inonu University, Malatya, TurkeyCorrespondence[email protected]

https://orcid.org/0000-0002-0030-5862 View further author information

Leyla BaharDepartment of Medical Services and Techniques, Vocational School of Health Services, Mersin University, Mersin, TurkeyView further author information

Emrah ZaymanDepartment of Histology and Embryology, Medical Faculty, Inonu University, Malatya, TurkeyView further author information

Nehir SucuDepartment of Cardiovascular Surgery, Medical Faculty, Mersin University, Mersin, TurkeyView further author information

Semir GülDepartment of Histology and Embryology, Medical Faculty, Inonu University, Malatya, TurkeyView further author information

Mehmet GülDepartment of Histology and Embryology, Medical Faculty, Inonu University, Malatya, Turkey

https://orcid.org/0000-0002-5721-8778 View further author information

ABSTRACT

We investigated the effects of α-lipoic acid (AL) and α-tocopherol (AT) on renal histopathology in a streptozotocin (STZ) induced diabetic rat model. Adult male rats were divided into six groups: group 1, saline only; group 2, AL only; group 3, AT only; group 4, STZ only; group 5, STZ + AL; group 6 STZ + AT. Experimental diabetes was induced by STZ. AL and AT were administered for 15 days. Kidney sections were examined using a light microscope after hematoxylin and eosin (H & E), periodic acid-Schiff (PAS) and caspase-3 staining. Histological damage to glomeruli, tubule epithelial cells and basement membrane was observed in group 4. Administration of AT and AL reduced renal injury in the diabetic rats. Group 5 exhibited a greater curative effect on diabetic rats than group 6. AT and AL may be useful for preventing diabetic renal damage.

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The authors declare no conflict of interest.

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Funding

This study was supported by the Research Support Unit of Mersin University under project no. 2017-1-AP2-2208.

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A light microscopic investigation of the renoprotective effects of α-lipoic acid and α-tocopherol in an experimental diabetic rat model

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A light microscopic investigation of the renoprotective effects of α-lipoic acid and α-tocopherol in an experimental diabetic rat model

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Declaration of interest

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