Thiacremonone, A New Inducer of Differentiation of Mammalian Cells from an Acremonium sp

A. Gehrt Lehrbereich Biotechnologie der Universität Kaiserslautern, Paul Ehrlich-Straβe 23, D-67663, Kaiserslautern, F.R.G

G. Erkel Lehrbereich Biotechnologie der Universität Kaiserslautern, Paul Ehrlich-Straβe 23, D-67663, Kaiserslautern, F.R.G

T. Anke Lehrbereich Biotechnologie der Universität Kaiserslautern, Paul Ehrlich-Straβe 23, D-67663, Kaiserslautern, F.R.G

O. Sterner Division of Organic Chemistry 2, Lund University, P.O.B. 124, S-221 00, Lund, Sweden

Abstract

Submerged fermentations of the fungus Acremonium sp. strain HA33-95 yielded thiacremonone, a new sulphur-containing derivative that induces the differentiation of mammalian cells at 31 μM. The isolation, structure determination and biological activities of thiacremonone are described.

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Thiacremonone, A New Inducer of Differentiation of Mammalian Cells from an Acremonium sp

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Thiacremonone, A New Inducer of Differentiation of Mammalian Cells from an Acremonium sp

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