New Potent Immunosuppressive Eremophilane Isolated from Trichothecium roseum

Hiroyukikawamura Department of Applied Biological Science and Research Institute of Science and Technology, Science University of Tokyo, Noda, Chiba, 278-8510, Japan

Maurizio Pulici The Institute of Physical and Chemical Research, Wako, Saitama, 351-0198, Japan

Hiroyuki Koshino The Institute of Physical and Chemical Research, Wako, Saitama, 351-0198, Japan

Yasuaki Esumi The Institute of Physical and Chemical Research, Wako, Saitama, 351-0198, Japan

Jun Uzawa The Institute of Physical and Chemical Research, Wako, Saitama, 351-0198, Japan

Hiroyuki Kumagai Central Research Laboratories, Mercian Corporation, Fujisawa, Kanagawa, 251-0057, Japan

Fumio Sugawara Department of Applied Biological Science and Research Institute of Science and Technology, Science University of Tokyo, Noda, Chiba, 278-8510, Japan

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Abstract

-A new sesquiterpene, cuspidatol (1), was isolated from Trichothecium roseum and its structure was elucidated by spectral analyses. This eremophilane type compound displays potent immunosuppressive activity, IC₅₀ 11μ/ml in MLR assay.

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New Potent Immunosuppressive Eremophilane Isolated from Trichothecium roseum

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New Potent Immunosuppressive Eremophilane Isolated from Trichothecium roseum

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