1,3-Dimethyl-8-Oxoisoguanine, A new purine from the New Zealand ascidian Pseudodistoma Cereum

Abstract

A new purine, 1,3-dimethyl-8-oxoisoguanine (2) was isolated from the New Zealand ascidian Pseudodistoma cereum. The structure of 2 was elucidated by the use of standard spectroscopic techniques, including natural abundance ¹H-¹⁵N 2D NMR.

Keywords:

• Purine
• Marine
• Ascidian
• 15N NMR

Acknowledgments

We gratefully acknowledge funding from the Auckland Medical Research Foundation and The University of Auckland Research Committee. DRA would like to thank The University of Auckland for the award of a Doctoral Scholarship. We wish to thank Mrs Gill Ellis for the P388, cytotoxicity and antimicrobial assays. We would also like to thank the Coral Reef Foundation (under contract from the NCI, Bethesda; supported by NIWA (NZ FRST contract C01809)) for collection of ascidian specimens.

Notes

^†Present address: 12001 11th Ave. NW, Seattle, WA 98177, USA.

Additional information

Notes on contributors

Gretchen Lambert†

†Present address: 12001 11th Ave. NW, Seattle, WA 98177, USA.