Novel Bioactive Azaphilones from Fruit Bodies and Mycelial Cultures of the Ascomycete Bulgaria inquinans (Fr.)

M. Stadler Division of Organic Chemistry 2, University of Lund, P.O.B. 124, S-221 00, Lund, Sweden

H. Anke Lehrbereich Biotechnologie der Universität Kaiserslautern, Paul Ehrlich-Str. 23, D-67663, Kaiserslautern, F.R.G.

K. Dekermendjian Department of Biochemistry, Research Institute of Biological Psychiatry, ST Hans Hospital, DK-4000, Roskilde, Denmark

R. Reiss Lehrbereich Biotechnologie der Universität Kaiserslautern, Paul Ehrlich-Str. 23, D-67663, Kaiserslautern, F.R.G.

O. Sterner Division of Organic Chemistry 2, University of Lund, P.O.B. 124, S-221 00, Lund, Sweden

R. Witt Department of Biochemistry, Research Institute of Biological Psychiatry, ST Hans Hospital, DK-4000, Roskilde, Denmark

Abstract

Three new azaphilones, bulgarialactone A (1), B (2) and C (3), were isolated from both the mycelia and fruit bodies of the Ascomycete Bulgaria inquinans. Bulgarialactone A (1) and B (2) possess antimicrobial, cytotoxic and nematicidal activities, and inhibit the binding of ³H-SCH 23390 to the dopamine D1 receptor. The isolation, structure determination and biological activities of the bulgarialactones are reported.

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Novel Bioactive Azaphilones from Fruit Bodies and Mycelial Cultures of the Ascomycete Bulgaria inquinans (Fr.)

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Novel Bioactive Azaphilones from Fruit Bodies and Mycelial Cultures of the Ascomycete Bulgaria inquinans (Fr.)

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