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Natural Product Letters Volume 8, 1996 - Issue 1
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Original Articles

Preparation of a Novel Paclitaxel / Docetaxel Derivative from Taxagifine

Jean-Noel Denis LEDSS, Chimie Recherche, Université Joseph Fourier, BP 53X, 38041, Grenoble Cédex 9, FRANCE
&
Andrew E. Greene LEDSS, Chimie Recherche, Université Joseph Fourier, BP 53X, 38041, Grenoble Cédex 9, FRANCE
Pages 27-32 | Published online: 04 Oct 2006
 
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Abstract

Taxagifine (1), an unusual taxane isolated from Taxus baccata and Taxus cuspidata (Taxaceae), has been efficiently transformed through C-13 reduction and acylation into the novel paclitaxel (Taxol®) / docetaxel (Taxotere®) derivative 5.

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