New Triterpenoidal Alkaloids from the Leaves of Buxus papillosa

Abstract

Two new triterpenoidal alkaloids, (+)-N _a, N _b-dimethylbuxupapine (1) (20S)-3β-dimethylamino-20-dimethylamino-9,10-seco-buxa-9(11),1(10)-dienel, and (+)-16a-hydroxypapillamidine (2) {(20S)-16α-hydroxy-3β-methyl-acetylamino-20-methylamino-9,10-seco-buxa-9(11),10(19)-diene} were isolated from the methanolic extract of the leaves of Buxus papillosa. The structures of these compounds were elucidated with the help of extensive spectroscopic studies. The structure of compound 1 was further confirmed by single crystal X-ray diffraction technique.

Key Words:

• Buxus papillosa
• (+)-N _a,N _b-dimethylbuxupapine
• (+)-16α-hydroxypapillamidine