A New Cytotoxic Prenylhydroquinone from a Mediterranean Tunicate of the Genus Aplydium

Ana Rueda Departamento de Química Orgánica, Facultad de Ciencias del Mar, Universidad de Cádiz, Apdo. 40, 11510 Puerto Real, Cádiz, Spain

Eva Zubía, María J. Ortega Departamento de Química Orgánica, Facultad de Ciencias del Mar, Universidad de Cádiz, Apdo. 40, 11510 Puerto Real, Cádiz, Spain

Javier Salvá Departamento de Química Orgánica, Facultad de Ciencias del Mar, Universidad de Cádiz, Apdo. 40, 11510 Puerto Real, Cádiz, Spain

Abstract

The mediterranean tunicate Aplydium sp. contains a new hydroxydiprenylhydroquinone 1 together with the known compound 2-[(2′E,6′E)-3′7′-dimethylocta-2′6′-dienyl]benzene-1,4-diol (2). The structure of 1 was elucidated by interpretation of spectral data. Both compounds showed significant cytotoxicity against four tumor cell lines, in particular, against P-388 mouse lymphoma suspension culture.

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A New Cytotoxic Prenylhydroquinone from a Mediterranean Tunicate of the Genus Aplydium

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A New Cytotoxic Prenylhydroquinone from a Mediterranean Tunicate of the Genus Aplydium

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