(-)-Frondosins A and D, HIV-Inhibitory Sesquiterpene Hydroquinone Derivatives from Euryspongia sp

Yali F. Hallock Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland, 21702-1201

John H. Cardellina II Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland, 21702-1201

Michael R. Boyd Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland, 21702-1201

Abstract

(-)-Frondosins A and D, two sesquiterpene hydroquinone metabolites, were isolated and identified from the HIV-inhibitory organic extracts of the marine sponge Euryspongia sp. In contrast to the decalin rings found previously in bicyclic marine sesquiterpene quinones and quinols, (-)-frondosins A and D possess the less common bicyclo[5.4.0]undecane sesquiterpene ring system.

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(-)-Frondosins A and D, HIV-Inhibitory Sesquiterpene Hydroquinone Derivatives from Euryspongia sp

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(-)-Frondosins A and D, HIV-Inhibitory Sesquiterpene Hydroquinone Derivatives from Euryspongia sp

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