Annodienin and Jahnonacin: New Bioactive Nontetrahydrofuran Annonaceous Acetogenins from the Twigs of Annona Jahnii

Trina Colman-saizarbitoria Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40-109, Caracas, Venezuela and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907, USA

Xiaoxi Liu Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40-109, Caracas, Venezuela and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907, USA

D. Craig Hopp Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40-109, Caracas, Venezuela and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907, USA

Holly A. Johnson Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40-109, Caracas, Venezuela and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907, USA

Feras Q. Alali Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40-109, Caracas, Venezuela and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907, USA

Lingling L. Rogers Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40-109, Caracas, Venezuela and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907, USA

Jerry L. McLaughlin Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40-109, Caracas, Venezuela and Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907, USA

show all

Abstract

Annodienin (1) and jahnonacin (2), two new bioactive non-tetrahydrofuran Annonaceous acetogenins, have been isolated from the EtOH extract of the twigs of Annona jahnii Saff., using fractionation directed by brine shrimp lethality. These new compounds are unsaturated acetogenins and have a diol system. Compound 1 bears two double bonds in the aliphatic chain. The structures were elucidated by spectral analyses of the parent compounds and/or simple chemical derivatives, especially by employing ¹H-NMR and 2D-NMR experiments. These acetogenins showed selective cytotoxicities, with potencies similar to adriamycin, among six human solid tumor cell lines.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Annodienin and Jahnonacin: New Bioactive Nontetrahydrofuran Annonaceous Acetogenins from the Twigs of Annona Jahnii

Information for

Open access

Opportunities

Help and information

Annodienin and Jahnonacin: New Bioactive Nontetrahydrofuran Annonaceous Acetogenins from the Twigs of Annona Jahnii

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature