Preparation and Research of Electrospinning Chitosan Nanofiber Sustained-Release Carrier

Abstract

In this paper, chitosan (CTS) nanofibers loaded Ca²⁺, Zn²⁺, Mg²⁺, Ce³⁺, ibuprofen and amoxicillin sustained-release carriers were prepared by electrospinning. The morphology, performance and structure were characterized by SEM, FTIR, TG and DTG, etc. Rheological analysis indicated that the viscosity of mixture solution was proportional to concentration of polymers, while surface tension had no relationship with it. SEM images revealed that the diameter of nanofibers varied from 25 nm to 70 nm, and the nanofibers which loaded 0.8% concentration of Ca²⁺ presented optimal spinning effect with a CTS/PVA ratio at 7:3. FTIR showed that loaded materials were successfully contained in electrospun nanofibers and had strong interaction with them.

Keyword:

• nanofiber
• chitosan fiber
• fiber carrier
• electrospinning