Synthesis of monodispersed pH-sensitive Ni_0.5Zn_0.5Fe₂O₄ magnetic nanoparticles and the potential medical application of adsorption for bovine serum album

ABSTRACT

We synthesized Ni_0.5Zn_0.5Fe₂O₄ magnetic nanoparticles (MNPs) by co-precipitation method and performed its adsorption of bovine serum albumin V(BSA (V)). The Ni_0.5Zn_0.5Fe₂O₄ MNPs in nitrogen atmosphere annealed at 400, 500, 600, 700 and 800°C, respectively. X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer(VSM) were used to characterize the resulting powders of the structure and properties. XRD results show that the Ni_0.5Zn_0.5Fe₂O₄ powder is a typical single-phase cubic spinel structure, and has no impurity phases. TEM results show that the Ni_0.5Zn_0.5Fe₂O₄ crystalline size is approximately 30–50 nm, which is similar with the XRD estimate results. The magnetic measurements show that Ni_0.5Zn_0.5Fe₂O₄ samples, super paramagnetic material, have high saturation magnetization and small coercivity properties. Moreover, We adopted ultraviolet spectrophotometer to analysis adsorption of BSA(V) on the Ni_0.5Zn_0.5Fe₂O₄ MNPs at room temperature, which show that annealed temperatures, pH, and stirring time can affect BSA(V) adsorption on the Ni_0.5Zn_0.5Fe₂O₄ MNPs. Most importantly, when ultrasonic stirring 2 hours in the liquor BSA(V) at pH = 7.0, the Ni_0.5Zn_0.5Fe₂O₄ samples annealed at 600°C has a highest value of 39.81mgg⁻¹. From above these results, Ni_0.5Zn_0.5Fe₂O₄ MNPs reveals a great adsorbing ability for BSA(V) that probable are a potential BSA-carrier candidate.

Keywords:

• Ni-Zn ferrite
• co-precipitation
• magnetic property
• bovine serum albumin protein
• adsorption

Acknowledgments

The authors would like to thank Jin-Kai Li from School of Physics and Optoelectric Engineering, Guangdong University of Technology in China for kindly offering the usage of XRD, VSM for the study of the fabrication of the Ni_0.5Zn_0.5Fe₂O₄ MNPs.

Funding

This project was supported financially by the National Natural Science Foundation of China (Grant Nos.10774030, 11032010 and 11202054) and the Guangdong Provincial of the Building of Strong Medicine Scientific Research Foundation of China (Grant No. 20151301).