Synthesis and Photothermal Application of D-A-D Conjugated Small Molecular Nanoparticles

Qiu-Bo Wanga Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, ChinaView further author information

Wang-Quan Zhanga Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, ChinaView further author information

Ying-Bin Sua Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, ChinaView further author information

Lin Yuana Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, ChinaView further author information

Bing Yua Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, China;b State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, ChinaView further author information

You-Qing Shena Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, ChinaView further author information

Hai-Lin Conga Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, China;b State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, ChinaCorrespondence[email protected]
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Abstract

The conjugated compound (3Z,6Z)-3,6-bis((5-(9,9-bis(2-octyldodecyl)-9H-fluoren-2-yl) thiophene-2-yl) methylene) piperazin-2,5-dione(p-QM2AF) was synthesized successfully. Nanoparticles (NPs) coated with p-QM2AF compound were prepared from liposomes. The morphology of NPs was characterized by transmission electron microscope and dynamic light scattering instrument, and the NPs maintained high stability after long time storage. Cytotoxicity test was used to evaluate the safety of nanoparticles, and the photothermal properties were characterized.

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Funding

This work is financially supported by the National Natural Science Foundation of China (21874078, 22074072), the Taishan Young Scholar Program of Shandong Province (tsqn20161027), the Major Science and Technology Innovation Project of Shandong Province (2018CXGC1407), the Key Research and Development Project of Shandong Province (2016GGX102028, 2016GGX102039, 2017GGX20111), and the First Class Discipline Project of Shandong Province.

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Synthesis and Photothermal Application of D-A-D Conjugated Small Molecular Nanoparticles

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Synthesis and Photothermal Application of D-A-D Conjugated Small Molecular Nanoparticles

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