Effect of Surface Modified Quartz Crystal Microbalance (QCM) on Detection Sensitivity for Prostate Specific Antigen (PSA)

Abstract

In this work, the surface-modified quartz crystal microbalance (QCM) was utilized for prostate cancer biomarker detection. The electroplating method was highly utilized to modify the QCMs. The influence of electroplating time, corresponding nanostructure formation and surface-modified electrode sensitivity are investigated. The estimated frequency shift for unmodified QCM is 39 Hz, 30-minute modified QCM is 213 Hz, and 60-minute modified QCs is 483 Hz. This method is practically convenient to improve the mass sensitivity of the PSA detector. The mass sensitivity of QCM increased with electroplating time.

Keywords:

• Quartz crystal microbalance (QCM)
• electroplating
• surface modification
• PSA

Acknowledgments

The authors would like to acknowledge the external grants and scholarships for graduate (One Research One graduate: OROG) for financial support. The authors are grateful for their comprehensive facilities and services from the BL6.1, Synchrotron Light Research Institute (SLRI), Nakhon Ratchasima, Thailand. I thank all the Smart Materials research group members for their support in this work.

Additional information

Funding

This work was supported by Suranaree University of Technology (SUT), Thailand.