Transduction Mechanisms From Biological Membranes to Silicon Sensors : Modelling and Computer Simulations

Massimo Grattarola Bioelectronics Laboratory, Department of Biophysical and Electronic Engineering (DIBE), Via Opera Pia 11a, 16145, Genova, Italy

Sergio Martinoia Bioelectronics Laboratory, Department of Biophysical and Electronic Engineering (DIBE), Via Opera Pia 11a, 16145, Genova, Italy

Giuseppe Massobrio Bioelectronics Laboratory, Department of Biophysical and Electronic Engineering (DIBE), Via Opera Pia 11a, 16145, Genova, Italy

Marco Bove Bioelectronics Laboratory, Department of Biophysical and Electronic Engineering (DIBE), Via Opera Pia 11a, 16145, Genova, Italy

Carlo Ciccarelli Bioelectronics Laboratory, Department of Biophysical and Electronic Engineering (DIBE), Via Opera Pia 11a, 16145, Genova, Italy

Abstract

A hybrid system consisting of a biological membrane (including an enzyme complex) in proximity (1 -10nm) to an ISFET is modelled. The response of the microelectronic device to a H+ production, resulting from the enzyme-mediated transduction of a chemical signal, is simulated. Both steady and transient conditions are considered. Finally, hypothetical chemical mechanisms resulting in output switching phenomena are briefly discussed.

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Transduction Mechanisms From Biological Membranes to Silicon Sensors : Modelling and Computer Simulations

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