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Original Articles

A Thermodynamic and NMR Investigation of 1-Lysopalmitoyllecithin / 1,2-Dipalmitoylphosphatidylethanolamine/Water System

, , , , , & show all
Pages 67-76 | Published online: 24 Sep 2006
 

Abstract

The effect of incorporation of 1-palmitoyl-sn-glycero-3-phosphocholine (PLPC) on the bilayer structures occurring in aqueous dispersions of 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) has been studied by phosphorus 31 nuclear magnetic resonance and calorimetric methods. The polymorphism of the system as a function of PLPC concentration has been defined. Experimental data allowed us to determine phase boundaries. Changes of molecular packing of the PLPC molecules in DPPE bilayers in the phase diagram are invoked to explain the experimental findings.

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