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Original Articles

Non-Conventional Agents for Optical Resolutions

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Pages 37-45 | Published online: 04 Oct 2006
 

Abstract

In this paper we demonstrate the use of chiral drugs and intermediates as resolving agents on 13 examples from our practice. In 11 cases of 13, the configuration of the enantiomers in the precipitated salt is opposite, which support the assumption that the formation of a “quasi racemate” type diastereoisomeric salt may be preffered, when the racemate and the resolving agent are structurally similar or at least there is no significant difference between their molecular weight.

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